OptoNeuro

OptoNeuro

Platform for OPTOgenetic NEUROn stimulation

 

Pleun P. Maaskant, Haymen Shams, Mahbub Akhter, William Henry, Menno J. Kappers, Dandan Zhu, Colin J. Humphreys, and Brian Corbett High-Speed Substrate-Emitting Micro-Light-Emitting Diodes for Applications Requiring High Radiance. Applied Physics Express 6 022102. 2013

 

Katona G, Szalay G, Maak P, Kaszas A, Veress M, Hillier D, Chiovini B, Vizi S, Roska B, Rozsa B. Fast two-photon in vivo imaging with three-dimensional random-access scanning in large tissue volumes. Nature Methods 8;9(2):201-8. 2012

 

Siegert S, Cabuy E, Gross Scherf B, Kohler H, Panda A, Le YZ, Fehling HJ, Gaidatzis DG, Stadler MB, Roska B. Transcriptional code and disease map for adult retinal cell types. Nature Neuroscience 22;15(3):487-95. 2012

 

Nack, M., Radu, I., Schultz, B.-J., Resler, T., Schlesinger, R., Bondar, A.-N., del Val, C., Abbruzzetti, S., Viappiani, C., Bamann, C., Bamberg, E., and Heberle, J. Kinetics of proton release and uptake by channelrhodopsin-2. FEBS Lett 586:1344-1348. 2012

 

Scholz F., Bamberg, E., Bamann, C., and Wachtveitl, J. Tuning the primary reaction of channelrhodopsin-2 by Imidazole, pH, and site-specific mutations. Biophys J 102:2649-2657. 2012

 

Müller, M., Bamann, C., Bamberg, E. & Kühlbrandt, W. Projection Structure of Channelrhodopsin-2 at 6 - Resolution by Electron Crystallography.. Journal of Molecular Biology , 414, 86-95. 2011

 

Al-Atabany, W, McGovern. B, Mehran, K., Berlinguer-Palmini, R, Degenaar, P., A processing platform for optoelectronic/optogenetic retinal prosthesis. IEEE Transactions on Biomedical Engineering , 2011 Nov 24. [Epub ahead of print]

 

Krol J, Busskamp V, Markiewicz I, Stadler MB, Ribi S, Duebel J, Oertner TO, Schübeler D, Schratt G, Fehling HJ, Richter J, Bibel M, Roska B and Filipowicz W, Characterization of microRNAs induced by light adaptation in mouse retina reveals rapid turnover as a common property of neuronal microRNAs. Cell , 2010 May 14;141(4):618-31

 

Kleinlogel,S., Terpitz,U., Legrum,B., Gükbuget,D., Boyden,E.S., Bamann,C., Wood,P.G., Bamberg,E. A gene-fusion strategy for stoichiometric and co-localized expression of light-gated membrane proteins. Nature Methods, 8, 12 1083-1088

 

Yonehara K., Balint K., Noda M., Nagel G., Bamberg E., Roska B., Spatially asymmetric reorganization of inhibition establishes a motion sensitive circuit. Nature 469:407-10 (2011).

 

Kleinlogel S., Feldbauer K., Dempski R.E., Fotis H., Wood P.G., Bamann C., Bamberg E., Ultra light-sensitive and fast neuronal activation with the Ca(2+)-permeable channelrhodopsin CatCh. Nat Neurosci. 14(4):513-8. (2011)

 

Grossman N., Nikolic K., Toumazou C., Degenaar P., Modeling study of the light stimulation of a neuron cell with Channelrhodopsin-2 Mutants. IEEE Transactions on Biomedical Engineering. Vol 58 (6) 1742-1751 June 2011

 

McGovern B., Palmini R.B., Grossman N., Drakakis E., Poher V., Neil M.A.A., Degenaar P., (2010), A new individually Addressable Micro-LED Array for photogenetic neural stimulation. IEEE Transactions on Biomedical Circuites and Systems. 4(6): 469-476.

 

Schultheis C, Liewald JF, Bamberg E, Nagel G, Gottschalk A. Optogenetic long-term manipulation of behavior and animal development. PLoS One. 2011 Apr 20;6(4):e18766.

 

Ruffert K, Himmel B, Lall D, Bamann C, Bamberg E, Betz H, Eulenburg V. Glutamate residue 90 in the predicted transmembrane domain 2 is crucial for cation flux through channelrhodopsin 2 Biochem Biophys Res Commun. 2011 Jul, 15;410(4):737-43

 

 

  • Review publications
  • Busskamp V, Picaud S, Sahel JA, Roska B Optogenetic therapy for retinitis pigmentosa Gene Therapy. 2011 Oct 13

     

    Busskamp V, Roska B. Optogenetic approaches to restoring visual function in retinitis pigmentosa Current Opinion in Neurobiology. 2011 Jun 25

     

    Azeredo da Silveira R, Roska B. Cell types, circuits, computation Current Opinion in Neurobiology. 2011 Oct;21(5):664-71.

     

     

  • Conference publications
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    2012 Young Researchers Futures Meeting on Neural Engineering (19-21st September): Presentation

     

    Photon 12 (IOP) (3-6th September): Poster

     

    Mahbub Akhter, Pleun Maaskant, Noreen Nudds, Peter O'Brien, Menno Kappers, and Colin Humphreys, "High performance individually addressable microLED arrays", 9th International Symposium on Semiconductor Light Emitting Devices (ISSLED 2012), Berlin, Germany, July 22-27, 2012.

     

    Post-graduate Symposium day at Imperial (June 2012): Poster

     

    Pleun Maaskant, Mahbub Akhter, Noreen Nudds, Peter O'Brien, Rolando Berlinguer Palmini, Patrick Degenaar, and Brian Corbett, "Adressable LED arrays for biophotonics applications", SPIE Photonics Europe 2012, Brussels, Belgium, April 16-20 2012.

     

    Degenaar P., McGovern B., Berlinguer-Palmini R., Vysokov N., Brossman N., Pohrer V., Drakakis E., Neil M., Individually addressable optoelectronic arrays for optogenetic neural stimulation. 2010 IEEE Biomedical Circuites and Systems Conference (BioCAS), 3-5 Nov 2010, p170-173.

     

    Al-Atabany W, Degenaar P., Scene Optimization for Optogenetic Retinal Prosthesis 2011 IEEE Biomedical Circuites and Systems Conference (BioCAS), San Diego, California, USA

     

    Pleun Maaskant, Mahbub Akhter, Noreen Nudds, Peter O'Brien, Patrick Degenaar, and Brian Corbett, Addressable LED arrays for biophotonics applications SPIE Photonics Europe 2012 (BioCAS), Brussels, Belgium, April 16-20 2012

     

     

  • Commercial publications
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    Concept commercial presentation, Scientifica stall, Society for Neuroscience (SFN), New Orleans, October 2012.

     

    Concept commercial presentation, Scientifica stall, 8th FENS Forum of Neuroscience - Barcelona July 2012.

     

  • Public engagement
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    Anab Jain, Jon Arden, Justin Pickard, Bjorn Roslett, Patrick Degenaar, Song of the Machine. Human Plus Exhibition, Dublin.

     

    Patrick Degenaar, See the world in a new light. Guardian Newspaper.

     

     

     

     

    Project No: 249867

     

    Action Duration: 2010 -- 2013

     

    animated Neuron

     

    Stimulation of a single neuron via microLED arrays