Platform for OPTOgenetic NEUROn stimulation


1. Berlinguer-Palmini R, Narducci R, Merhan K, Dilaghi A, Moroni F, Masi A, Scartabelli T, Landucci E, Sili M, Schettini A, McGovern B, Maskaant P, Degenaar P, Mannaioni G Arrays of MicroLEDs and Astrocytes: Biological Amplifiers to Optogenetically Modulate Neuronal Networks Reducing Light Requirement PLoS One 2014, 9(9), 7


2. Pleun P. Maaskant, Haymen Shams, Mahbub Akhter, William Henry, Menno J. Kappers, Dandan Zhu, Colin J. Humphreys, and Brian Corbett High-Speed Substrate-Emitting Micro-Light-Emitting Diodes for Applications Requiring High Radiance. Applied Physics Express 6 022102. 2013


3. Katona G, Szalay G, Maak P, Kaszas A, Veress M, Hillier D, Chiovini B, Vizi S, Roska B, Rozsa B. Fast two-photon in vivo imaging with three-dimensional random-access scanning in large tissue volumes. Nature Methods 8;9(2):201-8. 2012


4. Siegert S, Cabuy E, Gross Scherf B, Kohler H, Panda A, Le YZ, Fehling HJ, Gaidatzis DG, Stadler MB, Roska B. Transcriptional code and disease map for adult retinal cell types. Nature Neuroscience 22;15(3):487-95. 2012


5. Nack, M., Radu, I., Schultz, B.-J., Resler, T., Schlesinger, R., Bondar, A.-N., del Val, C., Abbruzzetti, S., Viappiani, C., Bamann, C., Bamberg, E., and Heberle, J. Kinetics of proton release and uptake by channelrhodopsin-2. FEBS Lett 586:1344-1348. 2012


6. Scholz F., Bamberg, E., Bamann, C., and Wachtveitl, J. Tuning the primary reaction of channelrhodopsin-2 by Imidazole, pH, and site-specific mutations. Biophys J 102:2649-2657. 2012


7. B. Corbett, R. Charash, B. Damilano, H. Kim-Chauveau, N. Cordero, H. Shams, J-M. Lamy, M. Akhter, P. P. Maaskant, E. Frayssinet, P. de Mierry, and J-Y. Duboz Current transport through an n-doped, nearly lattice matched GaN/AlInN/GaN heterostructure. Phys. Status Solidi C 9, No. 3-4, 931-933 (2012)


8. H. Kim-Chauveau, E. Frayssinet, B. Damilano, P. De Mierry, L. Bodiou, L. Nguyen, P. Vennegues, J.-M. Chauveau, Y. Cordier, J.Y. Duboz, R. Charash, A. Vajpeyi, J.-M. Lamy, M. Akhter, P.P. Maaskant, B. Corbett, A. Hangleiter, A. Wieck Growth optimization and characterization of lattice-matched Al0.82In0.18N optical confinement layer for edge emitting nitride laser diodes. Phys. Status Solidi C 9, No. 3-4, 931-933 (2012)


9. Ragh Charash, Hyonju Kim-Chauveau, Agam Vajpeyi, Mahbub Akther, Pleun P. Maaskant, Eric Frayssinet, Philippe de Mierry, Jean-Yves Duboz, and Brian Corbett Current transport through AlInN/GaN multilayers used as n-type cladding layers in edge emitting laser diodes Journal of Crystal Growth 338, 20-19 (2012)


10.Müller, M., Bamann, C., Bamberg, E. & Kühlbrandt, W. Projection Structure of Channelrhodopsin-2 at 6 - Resolution by Electron Crystallography.. Journal of Molecular Biology , 414, 86-95. 2011


11.R. Charash, H. Kim-Chauveau, J-M. Lamy, M. Akther, P. P. Maaskant, E. Frayssinet, P. de Mierry, A. D. Drager, J-Y. Duboz, A. Hangleiter and B. CorbettCleaved-facet violet laser diodes with lattice-matched Al0.82In0.18N/GaN multilayers as n-cladding Appl. Phys. Lett , 98, 201112 (2011)


12.Donagh O'Mahony, Russell Duane, Tony Campagno, Liam Lewis, Nicolas Cordero, Pleun Maaskant, Finbarr Waldron, Brian Corbett Thermal stability of SiC Schottky diode anode and cathode metalisations after 1000 h at 350 °C Microelectronics Reliability , Volume 51, Issue 5, 904-908 (2011)


13. Al-Atabany, W, McGovern. B, Mehran, K., Berlinguer-Palmini, R, Degenaar, P., A processing platform for optoelectronic/optogenetic retinal prosthesis. IEEE Transactions on Biomedical Engineering , 2011 Nov 24. [Epub ahead of print]


14. Kleinlogel,S., Terpitz,U., Legrum,B., Gükbuget,D., Boyden,E.S., Bamann,C., Wood,P.G., Bamberg,E. A gene-fusion strategy for stoichiometric and co-localized expression of light-gated membrane proteins. Nature Methods, 8, 12 1083-1088


15. Yonehara K., Balint K., Noda M., Nagel G., Bamberg E., Roska B., Spatially asymmetric reorganization of inhibition establishes a motion sensitive circuit. Nature 469:407-10 (2011).


16. Kleinlogel S., Feldbauer K., Dempski R.E., Fotis H., Wood P.G., Bamann C., Bamberg E., Ultra light-sensitive and fast neuronal activation with the Ca(2+)-permeable channelrhodopsin CatCh. Nat Neurosci. 14(4):513-8. (2011)


17. Grossman N., Nikolic K., Toumazou C., Degenaar P., Modeling study of the light stimulation of a neuron cell with Channelrhodopsin-2 Mutants. IEEE Transactions on Biomedical Engineering. Vol 58 (6) 1742-1751 June 2011


18. McGovern B., Palmini R.B., Grossman N., Drakakis E., Poher V., Neil M.A.A., Degenaar P., (2010), A new individually Addressable Micro-LED Array for photogenetic neural stimulation. IEEE Transactions on Biomedical Circuites and Systems. 4(6): 469-476.


19. Schultheis C, Liewald JF, Bamberg E, Nagel G, Gottschalk A. Optogenetic long-term manipulation of behavior and animal development. PLoS One. 2011 Apr 20;6(4):e18766.


20. Ruffert K, Himmel B, Lall D, Bamann C, Bamberg E, Betz H, Eulenburg V. Glutamate residue 90 in the predicted transmembrane domain 2 is crucial for cation flux through channelrhodopsin 2 Biochem Biophys Res Commun. 2011 Jul, 15;410(4):737-43


21. Krol J, Busskamp V, Markiewicz I, Stadler MB, Ribi S, Duebel J, Oertner TO, Schübeler D, Schratt G, Fehling HJ, Richter J, Bibel M, Roska B and Filipowicz W, Characterization of microRNAs induced by light adaptation in mouse retina reveals rapid turnover as a common property of neuronal microRNAs. Cell , 2010 May 14;141(4):618-31


22. Grossman N, Poher V, Grubb MS, Kennedy GT, Nikolic K, McGovern B, Palmini RB, Gong Z, Drakakis EM, Neil MAA, Dawson MD, Burrone J, Degenaar P. Multi-site optical excitation using ChR2 and micro-LED array Journal of Neural Eng. 2010 16004


23. Thomas Sattig, Christian Rickert, Prof.Dr. Ernst Bamberg, Prof.Dr. Heinz-Jurgen Steinhoff, Dr. Christian Bamann Light-Induced Movement of the Transmembrane Helix B in Channelrhodopsin-2 Angew Chem Int Ed Engl 26 JUL 2013 DOI: 10.1002/anie.201301698


24. Víctor A. Lorenz-Fonfria, Tom Resler, Nils Krause, Melanie Nack, Michael Gossing, Gabriele Fischer von Mollard, Christian Bamann, Ernst Bamberg, Ramona Schlesinger, and Joachim Heberle Transient protonation changes in channelrhodopsin-2 and their relevance to channel gating PNAS February 21, 2013 E1273-E1281, doi: 10.1073/pnas.1219502110



  • Review publications
  • 1. Barrett John, Berlinguer-Palmini Rolando, Degenaar Patrick. Optogenetic approaches to retinal prosthesis Visual Neuroscience 2014, 31(4-5), 345-354.


    2. Busskamp V, Picaud S, Sahel JA, Roska B Optogenetic therapy for retinitis pigmentosa Gene Therapy. 2011 Oct 13


    3. Busskamp V, Roska B. Optogenetic approaches to restoring visual function in retinitis pigmentosa Current Opinion in Neurobiology. 2011 Jun 25


    4. Azeredo da Silveira R, Roska B. Cell types, circuits, computation Current Opinion in Neurobiology. 2011 Oct;21(5):664-71.



  • Conference publications

    1. Walid Al-Atabany, Patrick Degenaar, "A coding scheme for optoelectronic/ optogenetic retinal prosthesis", (791) Biomedical Engineering - 2013, February 13 - 15, 2013 Innsbruck, Austria.


    2. Na Dong, Xiaohan Sun, Patrick Degenaar, "Implantable optrode design for optogenetic visual cortical prosthesis", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII , San Francisco, California, USA | January 21, 2012;


    3. Lionel Chaudet ; Mark Neil ; Patrick Degenaar ; Kamyar Mehran ; Rolando Berlinguer-Palmini ; Brian Corbet ; Pleun Maaskant ; David Rogerson ; Peter Lanigan ; Ernst Bamberg ; Botond Roska, "Development of optics with micro-LED arrays for improved opto-electronic neural stimulation", Proc. SPIE 8586, Optogenetics: Optical Methods for Cellular Control, San Francisco, California, USA | February 02, 2013;


    4. Walid Al-Atabany, Patrick Degenaar, "Efficient scene preparation and downscaling prior to stimulation in retinal prosthesis", IEEE Biomedical Circuits and Systems Conference (BioCAS 2013) Oct. 31 2013-Nov. 2 2013 Rotterdam.


    5. Walid Al-Atabany, Patrick Degenaar, "FPGA design of a pulse encoder for optoelectronic neural stimulation and recording arrays", IEEE Biomedical Circuits and Systems Conference (BioCAS 2013), Oct. 31 2013-Nov. 2 2013 Rotterdam.


    6. 2012 Young Researchers Futures Meeting on Neural Engineering (19-21st September)


    7. Photon 12 (IOP) (3-6th September):


    8. Mahbub Akhter, Pleun Maaskant, Noreen Nudds, Peter O'Brien, Menno Kappers, and Colin Humphreys, "High performance individually addressable microLED arrays", 9th International Symposium on Semiconductor Light Emitting Devices (ISSLED 2012), Berlin, Germany, July 22-27, 2012.


    9. Pleun Maaskant, Mahbub Akhter, Noreen Nudds, Peter O'Brien, Rolando Berlinguer Palmini, Patrick Degenaar, and Brian Corbett, "Adressable LED arrays for biophotonics applications", SPIE Photonics Europe 2012, Brussels, Belgium, April 16-20 2012.


    10. Degenaar P., McGovern B., Berlinguer-Palmini R., Vysokov N., Brossman N., Pohrer V., Drakakis E., Neil M., Individually addressable optoelectronic arrays for optogenetic neural stimulation. 2010 IEEE Biomedical Circuites and Systems Conference (BioCAS), 3-5 Nov 2010, p170-173.


    11. Al-Atabany W, Degenaar P., Scene Optimization for Optogenetic Retinal Prosthesis 2011 IEEE Biomedical Circuites and Systems Conference (BioCAS), San Diego, California, USA


    12. Pleun Maaskant, Mahbub Akhter, Noreen Nudds, Peter O'Brien, Patrick Degenaar, and Brian Corbett, Addressable LED arrays for biophotonics applications SPIE Photonics Europe 2012 (BioCAS), Brussels, Belgium, April 16-20 2012


    13. Chaudet, Lionel; Neil, Mark; Degenaar, Patrick; et al "Development of Optics with Micro-LED Arrays for Improved Opto-electronic Neural Stimulation" SPIE Photonics West Vol: 8586, Article: 85860R, FEB 02-03, 2013


    13. PMannaioni, G.; Palmini, R. Berlinguer; Mehran, K.; et al. "Improved super-bright microLEDs for bi-dimensional optogenetic applications and optoelectronic retinal prosthesis" Annual Meeting of the Neuroscience-Society Volume: 42, New Orleans, LA, USA , October 13 -17, 2012


    14. Palmini, R. Berlinguer; Narducci, R.; Mehran, K.; et al. "Improved super-bright microLEDs for bi-dimensional optogenetic applications and optoelectronic retinal prosthesis" 42nd Annual Meeting of the Society for Neuroscience, Volume: 42 , New Orleans, LA, USA , October 13 -17, 2012


    15. Dong, Na; Sun, Xiaohan; Degenaar, Patrick "Implantable Optrode Design for Optogenetic Visual Cortical Prothesis" Photonics West, Vol: 8207 Article Number: 82076A DOI: 10.1117/12.912386, San Francisco, CA JAN 21-24, 2012


    16. Degenaar, Patrick A "Optogenetic Visual Prosthesis - Engineering the optoelectronic stimulator" Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Volume: 2011 Pages: 1200, Ft Lauderdale, FL, USA , May 01 -05, 2011


    17. Grossman, N.; Nikolic, K.; Grubb, M. S.; et al. "High-frequency limit of neural stimulation with ChR2" IEEE Engineering in Medicine and Biology Society. Conference, , Vol: 2011 Pages: 4167-70 DOI: 10.1109/IEMBS.2011.6091034 Published:2011


    18. Grossman, N.; Nikolic, K.; Grubb, M. S.; et al. High-frequency limit of neural stimulation with ChR2. 33rd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS 2011), Pages: 4167-4170,


    19. Palmini, R. Berlinguer; McGovern, B.; Merhan, K.; et al. Talking to cells with light: MicroLEDs for two dimensional retinal prosthesis and optogenetic applications Society-for-Neuroscience Volume: 41, Washington, Nov 12 -16, 2011



  • Commercial activity

    1. Concept commercial presentation, Scientifica stall, Society for Neuroscience (SFN), New Orleans, October 2012.


    2. Concept commercial presentation, Scientifica stall, 8th FENS Forum of Neuroscience - Barcelona July 2012.


  • Public engagement

    1. Anab Jain, Jon Arden, Justin Pickard, Bjorn Roslett, Patrick Degenaar, Song of the Machine. Human Plus Exhibition, Dublin.


    2. Patrick Degenaar, See the world in a new light. Guardian Newspaper.





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